Non-Alcoholic Steatohepatitis and Bariatric Surgery
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چکیده
Non-alcoholic steatohepatitis (NASH) is a component of a wide spectrum of diseases that go from non-alcoholic fatty liver disease (NAFLD) to cirrhosis, and hepatocellular carcinoma in 40-60% of patients with NASH-related cirrhosis in a 5-7 year follow-up [1]. NASH has become one of the leading causes of liver disease in the developed world. With NAFLD believed to have doubled in the past 20 years [2], there is alerting evidence showing that these events are majorly secondary to the global epidemic of obesity [3,4].
منابع مشابه
Bariatric Surgery and Non-Alcoholic Fatty Liver Disease: Current and Potential Future Treatments
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are increasingly common cause of chronic liver disease worldwide. The diagnosis of NASH is challenging as most affected patients are symptom-free and the role of routine screening is not clearly established. Most patients with severe obesity who undergo bariatric surgery have NAFLD, which is associated insulin re...
متن کاملTreatment regimens for non-alcoholic fatty liver disease.
With the growing epidemic of obesity and diabetes, more attention has been placed on metabolic syndrome and its associated hepatic manifestation, non-alcoholic fatty liver disease (NAFLD). Within the spectrum of clinico-pathologic conditions known as NAFLD, only a minority of patients has the histological features characteristic of non-alcoholic steatohepatitis (NASH), which has the potential t...
متن کاملA new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients.
BACKGROUND Non-invasive approaches are useful to differentiate simple steatosis from non-alcoholic steatohepatitis (NASH) in obese and morbidly obese patients. AIM To develop a new scoring system to diagnose definitive NASH. METHODS Preoperative clinical and biological data including serum caspase 3-generated cytokeratin-18 fragments (CK18) and surgical liver biopsies were obtained from 464...
متن کاملThe spectrum of non alcoholic fatty liver disease in morbidly obese patients: prevalence and associate risk factors.
PURPOSE To determine the prevalence of non alcoholic fatty liver disease (NAFLD) and non alcoholic steatohepatitis (NASH) in morbidly obese patients undergoing bariatric surgery and to identify risk factors associated with the disease spectrum. METHODS Liver biopsy was performed in 60 patients who underwent bariatric surgery, after other causes of liver disease were excluded. Clinical, bioche...
متن کاملTreatment of non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is common and may progress to cirrhosis and its complications. The pathogenesis of steatosis and cellular injury is thought to be related mostly to insulin resistance and oxidative stress. Therefore, management entails identification and treatment of metabolic risk factors, improving insulin sensitivity, and increasing antioxidant defences in the liver....
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